Madrid, September 23 (EFE).- Spanish researchers have discovered why the immune system of some children does not respond to bronchiolitis or wheezing, conditions that can become chronic and lead to other types of diseases such as asthma.
The reason: the reduced presence of a biomarker (the microRNA called miR-146a-5p) in the airways of infants and children with these conditions, rendering these patients unable to control the inflammation generated in response to infection , and would explain the chronicity of these images.
The research, the results of which are published in the journal Cells, was carried out by a team from the network of the Center for Biomedical Research in Respiratory Diseases (CIBERES) and the Institute for Health Research Fundación Jiménez Díaz (IIS-FJD) , in collaboration with researchers from Hospital Severo Ochoa, Hospital de la Paz, University Alfonso X el Sabio and the National Center of Microbiology.
Carlos III of Madrid.
The research team focused on assessing the presence of this biomarker in babies with bronchiolitis and wheezing episodes, commonly associated with anti-inflammatory features, to investigate its possible role in these pathologies.
To do this, they performed molecular and cellular biology techniques using nasopharyngeal aspirate samples from infants with bronchiolitis (both during illness and after it was overcome), children with episodes of wheezing and healthy children of the same age recruited from hospitals. of the study.
Additionally, they used in vitro models of small airway epithelial cells from healthy individuals.
Specifically, “reduced expression of this biomarker was observed in the airways of babies with bronchiolitis and in samples from children who experienced episodes of wheezing, compared to controls,” Victoria detailed. del Pozo, head of the CIBERES group at Jiménez Díaz. Foundation Health Research Institute (IIS-FJD).
In children who overcame bronchiolitis, the presence of this marker was increased, “without however reaching the control levels of healthy children, and could be the key to the chronicity of the inflammation”, explained the researcher.